Scotland have only lifted the Calcutta Cup three times since the Six Nations began in 2000 but optimism is high ahead of Saturdays date with England. Scotland were whitewashed in the 2015 Six Nations with five defeats from five but some impressive performances during the World Cup - including that one point defeat to Australia in the quarter-finals - puts them in a good place ahead of their Murrayfield opener. Dean Ryan joins Alex Payne to preview the opening Six Nations clash between Scotland and England Englands failings at the World Cup are well documented, and while new coach Eddie Jones has not made wholesale changes to the squad, his focus on getting England back to their forward-dominant best has also seen confidence rise. We look at five points to look out for when the two sides face off.English underdogs? Vern Cotter has refuted claims Scotland are favourites to beat England Scotlands only win in their last 12 Six Nations games was a 21-20 win over Italy in Rome in 2014 and they have not beaten England since 2008. Despite this, Eddie Jones has labelled Vern Cotters side the favourites for Saturdays clash after the Scots narrowly missed out on a place in the World Cup semi-finals.Its so different us going up there as underdogs, said Jones. Scotland had a fantastic World Cup - they have excellent coaching staff and will be well prepared. Six Nations newcomers We look at 10 uncapped players looking to make an impact So for us its a game where we can restore some pride in English rugby against a Scottish team on top of the world.Cotter later laughed off Jones claims.I dont know how Eddie works that out, said the Scotland coach. Its just a psychological lever that hes trying to use, to take the pressure off himself.I gather that England are still ranked ahead of us by World Rugby. I didnt think England would need that, I thought they would be comfortable with the favourites tag.Sixes and sevens Scotland and Edinburgh flanker John Hardie in action against Japan The lack of a genuine fetcher appeared to plague England throughout the tenure of Stuart Lancaster, and now that Jones is in charge he has moved Chris Robshaw from the No 7 jersey into the No 6.Taking over the openside duties for England against Scotland is Wasps No 6 James Haskell, who previously made his feelings on the matter clear.People have got so obsessed about seven, six-and-a-half. Its bull. It doesnt matter, said the 30-year-old.The most important part of a back-row is the balance and people have got to stop worrying about what numbers youve got on a shirt. Six Nations predictions Alex Payne is tipping England to win this years tournament Youve got to each be exponents of all areas and this obsession with it has got to stop. Its not realistic. People havent seen that the modern game has completely changed from whats in the past. A seven now has a different role.Cotter obviously disagrees and has gone for two fetchers with John Hardie in the No 7 jersey and John Barclay wearing six.On the floor and at the breakdown Hardie is playing outstandingly well, said Sky Sports pundit Will Greenwood.He will look at that England team and say they have not got a seven. I think he will have a field day at the breakdown.No more Mr Nice Guy Scotlands WP Nel waiting for Englands front row The rallying call for England is to find their devil - find that intensity that means they do not take a backward step, and begin to rediscover that forward dominance that England were once known for.For Eddie, we have been too nice. In the past we have been a bit lax and now we have to find our motivation and reason to bring the devil, explained Billy Vunipola.If we lose a scrum and the opponents push us back then he wants us to have the attitude that next time you come around Im going to smash you.England will be up against it at the coal face though - WP Nel was absolutely superb at tighthead during the World Cup and will relish the chance to get stuck into Joe Marler who seems to be lacking a little confidence.The problem with Hartley Dylan Hartey hopes the disappointment of the World Cup will make Englands players hungrier for success It remains to be seen if new England captain Dylan Hartley can find that intensity that Jones craves while remaining calm and on the right side of the law. The selection of Hartley should come as no surprise as the set-piece was an area that England really struggled with at the World Cup - an area that England usually dominate.Hartleys experience and leadership is key to bring that dominance back and while a lot has been made of Hartleys disciplinary record and whether he has the right temperament to lead England, it is his staying power that is of concern. Ones to watch Jamie Weir asked all six captains for their player to watch... Hartley rarely lasts the full 80 minutes with the in-form Jamie George coming on at some stage, and the lack of leaders in the England team could be a problem.To combat that, Jones has named three vice-captains in Owen Farrell, Mike Brown and Billy Vunipola plus former captain Robshaw also has plenty of leadership experience, but will they step up in the heat of battle?Tactics Will Scotland target Owen Farrell (R) and George Ford (L)? Scotland may be optimistic but this is not an easy Six Nations for them - after England they face three away games against Wales, Italy and Ireland with their only other home game against France. Getting a win on Saturday is vital for them to get some momentum and they will be looking to target England anywhere they can.The George Ford and Owen Farrell combination is really exciting in terms of how England are going to attack but is it also an area that Scotland can exploit?I love that midfield combination of Ford and Farrell but it could also be an area that Scotland could attack, said Greenwood. Six Nations preview We preview the 2016 Six Nations Championship Farrell at No 12 is going to want to look after Ford and he likes to go chasing his hits. I think Scotland will look to get some moves in and around the No 10 and 12 channel to narrow Englands defence.Jonathan Joseph is not at his best just yet so I think they will look to expose him on the outside by getting three or four runners going around the corner. But for that to happen Scotlands pack have to carry hard and their platform has to be solid. Alex Payne picks out his favourite bets ahead of the Six Nations clash between Scotland and England Scotland: 15 Stuart Hogg, 14 Sean Maitland, 13 Mark Bennett, 12 Matt Scott, 11 Tommy Seymour, 10 Finn Russell, 9 Greig Laidlaw (c), 1 Alasdair Dickinson, 2 Ross Ford, 3 Willem Nel, 4 Richie Gray, 5 Jonny Gray, 6 John Barclay, 7 John Hardie, 8 David DentonReplacements: 16 Stuart McInally, 17 Gordon Reid, 18 Zander Fagerson, 19 Tim Swinson, 20 Blair Cowan, 21 Sam Hidalgo-Clyne, 22 Duncan Weir, 23 Duncan Taylor.England: 15 Mike Brown, 14 Anthony Watson, 13 Jonathan Joseph, 12 Owen Farrell, 11 Jack Nowell, 10 George Ford, 9 Danny Care; 1 Joe Marler, 2 Dylan Hartley (c), 3 Dan Cole, 4 Joe Launchbury, 5 George Kruis, 6 Chris Robshaw, 7 James Haskell, 8 Billy Vunipola.Replacements: 16 Jamie George, 17 Mako Vunipola, 18 Paul Hill, 19 Courtney Lawes, 20 Jack Clifford, 21 Ben Youngs, 22 Alex Goode, 23 Ollie Devoto. Dragan Bender Jersey . 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Daniel Ricciardo says this weekends Italian Grand Prix has underlined Mercedes big strengths after the reigning world champions dominated qualifying at Monza.Lewis Hamiltons pole position time was 0.837s quicker than the nearest non-Mercedes competitor on Saturday afternoon, with Ricciardos Red Bull 1.254s off Hamilton in sixth. Compared to the 0.149s margin Nico Rosberg had over Max Verstappen in Spa-Francorchamps last weekend, it is proof the gap between Mercedes and the rest of the field has increased significantly on arrival in Monza.The high-speed Italian track is always a trade-off between downforce and drag, with teams bringing slimmer rear wings to maximise top speeds on the straights, but Ricciardo says Mercedes powerful engine means they can enjoy the best of both worlds.This weekend they have definitely shown their strengths again, he said. It looks like Mercedes have a pretty decent sized rear wing as well. It seems that when they want they can sort of turn it up. Then again here last year as well I remember Mercedes were on another planet. For whatever reason we expected to probably be a bit down here.dddddddddddd. Perhaps we have a bit more drag on the car as well, so maybe that is another element that hurts us here.Coming back to Singapore [in two weeks] I think we will be competitive again, and I still think relatively perhaps straight line speeds are not too bad, but the question is are we using less downforce than them which then masks it a little bit. If we can get top five here we will walk away pretty happy.Rather than battling Mercedes, Ricciardo has his sights on Williams Valtteri Bottas in fifth place on the grid instead.I think theyll be a contender tomorrow, Valtteris long run yesterday looked quite good, I believe he had a new soft, but his pace seemed pretty good. I think theyll remain strong in the race, especially with their straight line speed, theyll put up a fight. 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